Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Histone Methylation: A Pivotal Epigenetic Driver of the Malignant Transformation of MASLD-HCC.

Journal of hepatocellular carcinoma·2026
Same author

Special correlation between diet and MASLD: positive or negative?

Cell & bioscience·2025
Same author

Decoding the role of immune T cells: A new territory for improvement of metabolic-associated fatty liver disease.

iMeta·2024
Same author

Ferulic acid ameliorates acetaminophen-induced acute liver injury by promoting AMPK-mediated protective autophagy.

IUBMB life·2022
Same author

Operational Networks: Adaptation to Extreme Events in China.

Risk analysis : an official publication of the Society for Risk Analysis·2020
Same author

Clinicopathological characteristics and survival outcomes of patients with coexistence of adenomyosis and endometrial carcinoma.

International journal of clinical and experimental pathology·2020

Related Experiment Video

Updated: Jun 25, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Hepatocellular Carcinoma Precursor Lesions: From Pathological Basis to Risk Stratification and Precision

Ruijuan Yan1,2, Haibo Zhang1,3, Junzhe Jiao1,2

  • 1Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, People's Republic of China.

Journal of Hepatocellular Carcinoma
|June 24, 2026
PubMed
Summary

Identifying hepatocellular carcinoma (HCC) precursor lesions is key for early diagnosis. This review details pathology, diagnostics, risk models, and emerging tech for better surveillance and intervention in liver cancer.

Keywords:
dysplastic noduleshepatocellular carcinomaliquid biopsyprecursor lesionsrisk prediction models

More Related Videos

Development and Optimization of A Human Hepatocellular Carcinoma Patient-Derived Organoid Model for Potential Target Identification and Drug Discovery
07:25

Development and Optimization of A Human Hepatocellular Carcinoma Patient-Derived Organoid Model for Potential Target Identification and Drug Discovery

Published on: August 18, 2023

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
06:38

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Related Experiment Videos

Last Updated: Jun 25, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Development and Optimization of A Human Hepatocellular Carcinoma Patient-Derived Organoid Model for Potential Target Identification and Drug Discovery
07:25

Development and Optimization of A Human Hepatocellular Carcinoma Patient-Derived Organoid Model for Potential Target Identification and Drug Discovery

Published on: August 18, 2023

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
06:38

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Area of Science:

  • Hepatology and Oncology
  • Pathology and Diagnostics
  • Biomarker Discovery

Background:

  • Hepatocellular carcinoma (HCC) develops from chronic liver disease, progressing through hepatitis, cirrhosis, and cancer.
  • HCC precursor lesions are critical for early detection and intervention.
  • Understanding these lesions is vital for improving patient outcomes.

Purpose of the Study:

  • To systematically review the pathological basis, malignant potential, and diagnostic approaches for HCC precursor lesions.
  • To summarize risk stratification strategies and precision intervention perspectives.
  • To explore the role of emerging technologies in HCC precursor lesion management.

Main Methods:

  • Review of pathological characteristics of lesions like dysplastic foci and hepatocellular adenoma.
  • Evaluation of imaging modalities including ultrasound, CT, and MRI.
  • Analysis of serum and liquid biopsy markers (AFP, ctDNA, etc.).
  • Assessment of multivariable risk models (aMAP, GALAD, THRI).

Main Results:

  • Various HCC precursor lesions exhibit distinct pathological features and malignant potential.
  • Imaging techniques show value and limitations in screening and diagnosis.
  • Biomarkers and risk models aid in risk stratification and monitoring.
  • Emerging technologies like AI and radiomics show promise but require further validation.

Conclusions:

  • HCC precursor lesions are crucial targets for early surveillance and precise intervention.
  • Integrated application of pathology, imaging, biomarkers, and technology can enhance early identification and management.
  • Bridging the gap between research and clinical implementation is essential for advancing HCC prevention.