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A4 amyloid protein immunoreactivity is present in Alzheimer's disease neurofibrillary tangles
B T Hyman1, G W Van Hoesen, K Beyreuther
1Department of Neurology, University of Iowa College of Medicine, Iowa City 52242.
Neuroscience Letters
|July 3, 1989
Abstract:
Neurofibrillary tangles and neuritic plaques are the neuropathological hallmarks of Alzheimer's disease. The latter consist of a core of A4 amyloid protein. We now report that some neurofibrillary tangles ('tombstone tangles') are also A4 immunoreactive. This observation is consistent with the hypothesis that A4 amyloid accumulation is a component of both neurofibrillary tangles and neuritic plaques.