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The cytotoxic activity of Ziziphus Jujube on cervical cancer cells: In Vitro study

R Hoshyar1, S Jamali1, M Fereidouni2

  • 1Birjand University of Medical Sciences Cellular & Molecular Research Center Birjand Iran.

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|January 1, 2016
PubMed

Insights

Ziziphus Jujube (Jujube) demonstrates anti-cancer properties by inhibiting cervical cancer cell proliferation. It alters cell cycle gene expression, suggesting potential as a natural therapeutic agent.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products Research

Background:

  • Growing interest in natural products like Ziziphus Jujube (Jujube) for cancer therapy.
  • Need to understand the molecular mechanisms of Jujube's anti-cancer effects for cervical cancer treatment.

Purpose of the Study:

  • To investigate the molecular mechanisms behind Jujube's anti-cancer effects on cervical cancer cells.
  • To evaluate the impact of Jujube on cell proliferation and key cell cycle regulatory genes.

Main Methods:

  • MTT assay to assess cell proliferation inhibition.
  • Quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR) to analyze gene expression levels.

Main Results:

  • Jujube significantly inhibited OV-2008 cervical cancer cell proliferation in a dose- and time-dependent manner.
  • Jujube treatment suppressed cyclin D1 expression.
  • Jujube treatment enhanced the expression of tumor suppressor genes P53, P21, and P27.

Conclusions:

  • Jujube exhibits cytotoxic effects on cervical cancer cells.
  • The anti-cancer activity of Jujube is mediated through the regulation of cell cycle genes.
  • Jujube holds potential as a natural therapeutic agent for cervical cancer.

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