Immunohistochemical studies of Peters' anomaly

Peters' anomaly is a congenital abnormality that affects mainly the posterior cornea. The pathogenesis is unclear. By immunohistochemical methods, the authors determined the presence of extracellular matrix proteins, including fibronectin, laminin, and collagen types I, III, IV, V, and VI, in seven corneal buttons from five patients with Peters' anomaly. Type III collagen was the only protein absent in either the pathologic or normal human corneas. Compared with normal controls, the stromal lamellae in Peters' anomaly corneas were more irregular and more closely packed. In addition, the fibronectin staining was markedly enhanced in all seven Peters' anomaly corneas. Staining with collagen type VI was also mildly increased. These results suggest that extracellular matrix elements such as fibronectin may be important factors in this developmental disorder.