Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

8.6K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
8.6K
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

1.9K
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
1.9K
Dialysis01:27

Dialysis

2.0K
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
2.0K
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

1.1K
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
1.1K
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

549
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
549
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

1.1K
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hafnium-Substituted Wells-Dawson Polyoxometalate as a High-Performance Contrast Agent for Transmission Electron Microscopy of Biological Ultrastructure.

International journal of molecular sciences·2026
Same author

Non-Destructive Characterization of Cultural Heritage Materials Using a Modified Acoustic Resonance Approach.

Materials (Basel, Switzerland)·2026
Same author

Injury Epidemiology in Elite U17 Football Players: A Prospective Study Across Six Competitive Seasons.

Life (Basel, Switzerland)·2026
Same author

Linking satellite-derived vegetation health parameters to arborist ground observations in urban environment.

Scientific reports·2026
Same author

Pathological and Diagnostic Assessment of Duodenal Wound Healing: A Comparative Experimental Study of Jejunal Serosal vs. ePTFE Patch Repair.

Medicina (Kaunas, Lithuania)·2026
Same author

Lycopene Mitigates Rat Liver Damage Induced by Lipopolysaccharide via Mechanisms Involving Oxidative Stress, Inflammation, and Apoptosis.

Current issues in molecular biology·2025

Related Experiment Video

Updated: Mar 28, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.9K

Endothelial Dysfunction in Renal Failure: Current Update.

Miroslav Radenkovic1, Marko Stojanovic, Milica Prostran

  • 1Department of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, PO Box 38, 11129 Belgrade, Serbia. mradenkovic@med.bg.ac.rs.

Current Medicinal Chemistry
|January 1, 2016
PubMed
Summary
This summary is machine-generated.

Endothelial dysfunction, marked by impaired vascular relaxation and increased oxidative stress, is a key factor in kidney disease progression. This review highlights recent findings on its role in renal failure.

More Related Videos

Intravascular Delivery of Biologics to the Rat Kidney
07:29

Intravascular Delivery of Biologics to the Rat Kidney

Published on: September 1, 2016

8.3K
Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

19.0K

Related Experiment Videos

Last Updated: Mar 28, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.9K
Intravascular Delivery of Biologics to the Rat Kidney
07:29

Intravascular Delivery of Biologics to the Rat Kidney

Published on: September 1, 2016

8.3K
Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

19.0K

Area of Science:

  • Cardiovascular Biology
  • Nephrology
  • Vascular Medicine

Background:

  • Endothelial dysfunction involves impaired vascular relaxation due to reduced nitric oxide and increased oxidative stress.
  • It is increasingly recognized as a significant factor in the development and progression of kidney impairment and renal failure.
  • Understanding endothelial dysfunction is crucial for comprehending kidney disease pathophysiology.

Purpose of the Study:

  • To review recent scientific literature on the link between endothelial dysfunction and renal failure.
  • To synthesize current knowledge on biomarkers and clinical findings related to this association.
  • To provide a comprehensive overview of endothelial dysfunction's role in kidney disease progression.

Main Methods:

  • Systematic review of relevant scientific articles.
  • Selection of studies published between 2010 and 2015.
  • Analysis of data on endothelial dysfunction markers and renal impairment.

Main Results:

  • Endothelial dysfunction is characterized by reduced endothelium-dependent vasodilation and increased vascular tone.
  • Key factors include decreased nitric oxide bioavailability, oxidative stress, and inflammation.
  • Vascular changes associated with endothelial dysfunction are prominent in kidney disease progression.

Conclusions:

  • Endothelial dysfunction plays a critical role in the pathogenesis of kidney impairment and renal failure.
  • Further research into biomarkers and clinical manifestations is essential for a comprehensive understanding.
  • Targeting endothelial dysfunction may offer therapeutic strategies for kidney disease.