Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

247
The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
247
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

135
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
135
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

224
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
224
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

262
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
262
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

2.2K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.2K
Factors Influencing Heart Rate01:30

Factors Influencing Heart Rate

5.7K
The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cerebral Hemodynamics Are Related to Cortical Brain Morphology in Heart Failure with Reduced Ejection Fraction Independent of Reduced Cardiac Output.

CJC open·2026
Same author

Actionable arrhythmias in low-risk patients with ST segment elevation myocardial infarction (STEMI): role for continued telemetry beyond 24-48 h.

American heart journal plus : cardiology research and practice·2025
Same author

Sodium-Glucose Cotransporter 2 Inhibitors Preceding ST-Segment Elevation Myocardial Infarction: Global Proteomics and Pathobiological Insights.

JACC. Advances·2025
Same author

Cardiac dysfunction is associated with indices of brain atrophy and cognitive impairment in heart failure with reduced ejection fraction.

Journal of applied physiology (Bethesda, Md. : 1985)·2025
Same author

Cerebrovascular responses to muscle metaboreflex activation in patients living with heart failure with reduced ejection fraction.

Journal of applied physiology (Bethesda, Md. : 1985)·2025
Same author

Assessment of the Sensitivity of a Smartphone App to Assist Patients in the Identification of Stroke and Myocardial Infarction: Cross-Sectional Study.

JMIR formative research·2025

Related Experiment Video

Updated: Nov 19, 2025

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

398

Heart rate and heart failure.

Amelia M C Yip1, Alexander B Zhai, Haissam Haddad

  • 1Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

Current Opinion in Cardiology
|January 1, 2016
PubMed
Summary

Resting heart rate is a risk factor for heart failure. Ivabradine, a heart rate-lowering drug, reduced cardiovascular events in patients with left ventricular systolic dysfunction, but causality remains unclear.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Resting heart rate is a known risk factor for cardiovascular disease and a prognostic indicator in heart failure.
  • Beta-blockers are used in heart failure management for heart rate control and their negative inotropic effects.
  • The specific contribution of isolated heart rate reduction to outcomes in left ventricular systolic dysfunction is not fully understood.

Purpose of the Study:

  • To review the role of isolated heart rate modification in left ventricular systolic dysfunction.
  • To evaluate the impact of ivabradine, a selective If channel inhibitor, on cardiovascular outcomes in heart failure patients.

Main Methods:

  • Analysis of two recent clinical trials investigating ivabradine in heart failure.
  • Assessment of heart rate-lowering effects and cardiovascular outcomes associated with ivabradine therapy.

More Related Videos

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

1.7K
Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
10:08

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

13.8K

Related Experiment Videos

Last Updated: Nov 19, 2025

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

398
Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

1.7K
Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
10:08

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

13.8K

Main Results:

  • Ivabradine significantly lowered heart rate and cardiovascular events in patients with left ventricular systolic dysfunction and baseline heart rate ≥70 bpm.
  • The cardiovascular benefits observed with ivabradine are presumed to be primarily due to its heart rate-lowering effects, with minimal other cardiotropic actions at the studied doses.

Conclusions:

  • While ivabradine demonstrated a reduction in cardiovascular events, causality between heart rate reduction and improved outcomes was not definitively proven.
  • The precise relationship between heart rate and cardiovascular outcomes in heart failure requires further investigation.