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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

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Types of RNA01:20

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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RNA-seq03:21

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
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Updated: Mar 28, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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NONCODEv4: Annotation of Noncoding RNAs with Emphasis on Long Noncoding RNAs.

Yi Zhao1, Jiao Yuan2, Runsheng Chen3

  • 1Key Laboratory of Intelligent Information Processing, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, 100190, China.

Methods in Molecular Biology (Clifton, N.J.)
|January 2, 2016
PubMed
Summary

The NONCODEv4 database offers a comprehensive catalog of long noncoding RNAs (lncRNAs), detailing over 200,000 lncRNAs and their functions. This resource aids in understanding lncRNA roles in biological processes and tissue physiology.

Keywords:
ExpressionFunctionSequencinglncRNAlncRNA gene

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Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • High-throughput sequencing and bioinformatics enable the detection and profiling of numerous noncoding transcripts.
  • Long noncoding RNAs (lncRNAs), exceeding 200 nucleotides, play crucial roles in biological processes and tissue physiology.

Purpose of the Study:

  • To introduce NONCODEv4, a database providing a comprehensive catalog and detailed annotations for lncRNAs.
  • To explore the concept of lncRNA genes, their expression, and functions using public transcriptome data.

Main Methods:

  • Utilizing public transcriptome data for analysis.
  • Developing a user-friendly web interface with integrated online tools.

Main Results:

  • NONCODEv4 catalogs over half a million transcripts, including more than 200,000 lncRNAs.
  • The database supports the exploration of lncRNA gene expression and function.

Conclusions:

  • NONCODEv4 serves as a valuable resource for lncRNA research.
  • The database facilitates the study of lncRNA roles in biological systems.