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Myokit: A simple interface to cardiac cellular electrophysiology
Michael Clerx1, Pieter Collins2, Enno de Lange2
1Department of Data Science and Knowledge Engineering, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands; Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.
Progress in Biophysics and Molecular Biology
|January 2, 2016
Summary
Myokit is a new software tool for cardiac cellular electrophysiology modeling and simulation. It offers a user-friendly interface and powerful analysis tools, bridging the gap between simple and complex simulation software.
Area of Science:
- Computational Biology
- Biophysics
- Cardiovascular Research
Background:
- Existing cardiac cellular electrophysiology simulation tools often present a trade-off between ease of use and advanced functionality.
- A gap exists between user-friendly but limited software and powerful tools requiring significant programming expertise.
Purpose of the Study:
- To introduce Myokit, a novel software tool designed to address limitations in current cardiac cellular electrophysiology modeling and simulation.
- To demonstrate Myokit's capabilities in facilitating model development, simulation, and analysis with minimal user programming effort.
Main Methods:
- Development of Myokit, featuring an intuitive modeling language, graphical user interface, and integrated simulation engines.
- Implementation of robust import/export functionalities for various formats (CellML, C, MATLAB, CUDA, OpenCL).
- Utilizing patch-clamp data for parameter estimation within Myokit.
Main Results:
- Myokit provides a versatile platform for cardiac cellular electrophysiology, integrating a user-friendly modeling language with powerful simulation and analysis tools.
- Demonstrated successful application of Myokit in clinically relevant investigations, multi-model testing, and parameter estimation for Markov models.
- Myokit effectively bridges the performance, versatility, and user-friendliness gap in cardiac electrophysiology simulation software.
Conclusions:
- Myokit offers a powerful yet accessible solution for cardiac cellular electrophysiology modeling and simulation.
- The software facilitates advanced research, including parameter estimation and multi-model testing, with reduced programming requirements.
- Myokit enhances the development and application of cardiac electrophysiology models for scientific and clinical investigations.
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