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Updated: Mar 28, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
MRC-SPECT: A sub-500 μm resolution MR-compatible SPECT system for simultaneous dual-modality study of small animals
Liang Cai1, Xiaochun Lai1, Zengming Shen1
1Department of Nuclear, Plasma, and Radiological Engineering, University of Illinois at Urbana Champaign, Urbana, USA.
Abstract:
In this paper, we will report the development of an ultrahigh resolution MR-compatible SPECT system that can be operated inside a pre-existing clinical MR scanner for simultaneous dual-modality imaging of small animals. This system is constructed with 40 small-pixel CdTe detector modules assembled in a fully stationary ring SPECT geometry. We have experimentally demonstrated that this system is capable of providing an imaging resolution of <500 μm when operating inside MR scanners. We will report the design, construction of the MRI-compatible SPECT system, including the detector technology, collimator, system development and so on. The first imaging results obtained with this newly constructed SPECT system will also be reported.

