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Updated: Mar 28, 2026
Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
Published on: August 21, 2017
Seronegative neuromyelitis optica after cardiac transplantation
Elecia Kim1, Michael Van Vrancken1, Mohamed Shaji1
1Department of Internal Medicine (Kim), Department of Pathology (Van Vrancken), Division of Neurology (Mir, Shamim), Division of Infectious Diseases (Spak), and Division of Neuroradiology (Gupta), Baylor University Medical Center at Dallas.
Abstract:
We report a case of a 42-year-old man who presented with progressive weakness and blindness over the course of several months and met criteria for seronegative neuromyelitis optica. This presentation was in the setting of immunosuppression following cardiac transplant. No infectious causes were found within the neuroaxis, and he ultimately died with complete blindness, quadriplegia, and respiratory failure attributed to panmyelitis and brain stem inflammation despite aggressive therapies.
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