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Treatment alternatives for invasive bladder cancer
1Department of Surgery, University of Florida College of Medicine, Gainesville 32610.
Seminars in Surgical Oncology
|January 1, 1989
Summary
Radical cystectomy for muscle invasive bladder cancer is being improved with new treatments. Combination chemotherapy and bladder-preserving therapies offer better survival and function.
Area of Science:
- Oncology
- Urology
Background:
- Radical cystectomy is the standard for muscle invasive bladder cancer but has high failure rates and morbidity.
- Alternative and modified treatments are being explored due to the limitations of radical cystectomy.
Purpose of the Study:
- To review advancements in the treatment of invasive bladder cancer.
- To highlight new therapeutic strategies that improve survival and preserve bladder function.
Main Methods:
- Review of current literature on bladder cancer treatment modalities.
- Analysis of combination chemotherapy regimens, conservative surgical excision, and radiation therapy techniques.
Main Results:
- Methotrexate-platinum-based chemotherapy shows efficacy in advanced bladder cancer.
- Conservative surgical excision and radiation therapy (interstitial or with radiosensitizers) can achieve long-term survival and bladder preservation.
- Multimodality treatments are demonstrating comparable outcomes to radical cystectomy.
Conclusions:
- Significant progress has been made in improving survival rates for invasive bladder cancer.
- New treatment strategies offer the potential for effective disease management while preserving bladder function.
- Mixed multimodality treatments represent a landmark in developing ideal treatments for invasive bladder cancer.