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Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

3D bioprinting for engineering complex tissues.

Christian Mandrycky¹, Zongjie Wang², Keekyoung Kim²

¹Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.

Biotechnology Advances

|January 3, 2016

Summary

This summary is machine-generated.

3D bioprinting fabricates living tissues using cell-laden biomaterials. Despite challenges in resolution and vascularization, it offers potential for regenerative medicine and drug screening.

Keywords:

3D printing Bioink Bioprinting Drug screening Hydrogel Regenerative medicine Tissue engineering

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Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

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Published on: August 11, 2017

Area of Science:

Biomedical Engineering
Regenerative Medicine
Tissue Engineering

Background:

3D bioprinting utilizes precise deposition of cell-laden biomaterials to construct functional living tissues.
Current applications show promise in regenerative medicine for tissues like skin, cartilage, and bone.
Significant technical hurdles remain, including high-resolution cell patterning, vascularization, and innervation.

Purpose of the Study:

To review the fundamental principles, materials, integration strategies, and applications of 3D bioprinting.
To discuss recent advancements, persistent challenges, and future directions in bioprinting for complex tissue engineering.
To highlight the potential of 3D bioprinting combined with stem cell technology for drug screening and regenerative therapies.

Main Methods:

Review of existing literature on 3D bioprinting technologies and applications.
Analysis of current challenges in achieving high-resolution cell deposition and complex tissue architectures.
Exploration of integration strategies for vascularization and innervation in bioprinted constructs.

Main Results:

Bioprinting is a versatile, on-demand fabrication technique with potential to address organ shortages.
It enables high-throughput cell patterning at the micrometer scale for diverse biomedical applications.
3D bioprinted tissue models, especially with human pluripotent stem cells, show promise for drug discovery and regenerative medicine.

Conclusions:

3D bioprinting is a rapidly evolving field with significant potential in tissue engineering and regenerative medicine.
Overcoming challenges in resolution, vascularization, and innervation is crucial for clinical translation.
The synergy between bioprinting and stem cell technology opens new avenues for personalized therapies and predictive toxicology.