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Impulsive mathematical modeling of ascorbic acid metabolism in healthy subjects
Mostafa Bachar1, Jochen G Raimann2, Peter Kotanko3
1Department of Mathematics, College of Sciences, King Saud University, Riyadh, Saudi Arabia.
Abstract:
In this work, we develop an impulsive mathematical model of Vitamin C (ascorbic acid) metabolism in healthy subjects for daily intake over a long period of time. The model includes the dynamics of ascorbic acid plasma concentration, the ascorbic acid absorption in the intestines and a novel approach to quantify the glomerular excretion of ascorbic acid. We investigate qualitative and quantitative dynamics. We show the existence and uniqueness of the global asymptotic stability of the periodic solution. We also perform a numerical simulation for the entire time period based on published data reporting parameters reflecting ascorbic acid metabolism at different oral doses of ascorbic acid.
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