[Conventional insulin treatment and treatment using multiple injections in diabetes mellitus]

The relationship between development of late diabetic complications and the degree of diabetic control is discussed and thus also the indications for intensive insulin treatment. To promote improved understanding of the basis for treatment with multiple insulin injections, regulation of glucose metabolism in normal individuals is reviewed. The practical management in different insulin regimes and the advantages and disadvantages of these are mentioned. In particular, problems in connection with the "early morning phenomenon", postprandial hyperglycaemia and day-to-day variations in insulin absorption are emphasized.