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IgG4-related disease: what urologists should know
1Department of Urology, Policlinico Tor Vergata, Viale Oxford, 81, 00133, Rome, Italy. danielebianchimail@yahoo.it.
International Urology and Nephrology
|January 4, 2016
Summary
Immunoglobulin G4-related disease (IgG4-RD) can affect any urologic site, often mimicking malignancies and leading to misdiagnosis. Urologists need to conduct preliminary assessments to avoid incorrect treatments for this rare condition.
Area of Science:
- Urology
- Immunology
- Pathology
Background:
- Immunoglobulin G4-related disease (IgG4-RD) is a chronic fibro-inflammatory condition.
- Urologic involvement is increasingly recognized but often underdiagnosed.
- IgG4-RD can present with tumefactive lesions or organ failure.
Purpose of the Study:
- To review urologic manifestations of IgG4-RD.
- To equip urologists with knowledge for preliminary assessment of IgG4-RD.
- To aid in the differential diagnosis of urologic diseases.
Main Methods:
- Systematic literature search of PubMed and Google databases.
- Keywords included IgG4 and specific urologic organs/sites.
- Articles published up to October 2015 were reviewed.
Main Results:
- IgG4-RD is a systemic disease with potential involvement of all urologic sites.
- It frequently mimics urologic malignancies.
- Rarity contributes to frequent misdiagnosis.
Conclusions:
- A multidisciplinary approach is essential for managing IgG4-RD.
- Urologists must consider IgG4-RD in differential diagnoses.
- Preliminary assessments are crucial to prevent inappropriate urologic treatments.
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