Universal screening for chronic hepatitis C virus

Area of Science:

• Hepatology
• Infectious Diseases
• Public Health

Background:

• Chronic hepatitis C virus (HCV) infection impacts 123 million globally.
• HCV is a primary cause of liver cirrhosis and hepatocellular carcinoma.
• A significant portion of those infected (75%) belong to the 1945-1965 birth cohort.

Purpose of the Study:

• To highlight the limitations of current HCV screening recommendations.
• To advocate for universal HCV screening.
• To address the barriers in accessing treatment for identified HCV cases.

Main Methods:

• Analysis of global HCV infection statistics.
• Review of current screening guidelines and their application.
• Assessment of treatment accessibility challenges.

Main Results:

• Current screening recommendations targeting the 1945-1965 birth cohort are not fully implemented.
• Many individuals who could benefit from treatment are missed due to cohort-specific screening.
• Treatment access remains a significant obstacle for diagnosed HCV patients worldwide.

Conclusions:

• Universal screening for HCV is optimal for comprehensive disease control.
• Expanding screening beyond the 1945-1965 birth cohort is necessary.
• Addressing treatment restrictions is critical to effectively manage chronic HCV infection.