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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Role of Vitamins in Maintaining Bone Health01:25

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
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The Bone Matrix01:18

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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[Bone quality and strength relating with bone remodeling].

Satoshi Mori1

  • 1Department of Bone & Joint Surgery, Seirei Hamamatsu General Hospital, Japan.

Clinical Calcium
|January 6, 2016
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Summary
This summary is machine-generated.

Bone strength relies on bone remodeling, which maintains mineral balance and structural integrity. Both high and low bone turnover rates negatively impact bone strength through different mechanisms.

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Area of Science:

  • Bone Biology
  • Skeletal Physiology
  • Biomineralization

Context:

  • Bone remodeling is crucial for adult bone metabolism, replacing old bone with new.
  • Bone strength is determined by volume, structure, and quality (micro-damage, mineralization, collagen cross-linking).

Purpose:

  • To elucidate the relationship between bone remodeling dynamics and bone strength.
  • To understand how altered bone turnover affects skeletal integrity.

Summary:

  • Bone remodeling regulates bone volume, structure, and quality, thereby controlling bone strength.
  • High bone turnover decreases bone strength by reducing volume and structural integrity.
  • Low bone turnover decreases bone strength by increasing micro-damage, mineralization, and collagen cross-linking.

Impact:

  • Provides insights into the mechanisms underlying bone fragility in different turnover states.
  • Highlights the critical role of balanced bone remodeling for maintaining skeletal health.
  • Informs potential therapeutic strategies targeting bone remodeling for skeletal disorders.