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Related Experiment Videos

Hemodynamic studies in sickle cell disease.

G P Rodgers1, C T Noguchi, A N Schechter

  • 1Laboratory of Chemical Biology, National Institutes of Diabetes, and Digestive and Kidney Diseases, Bethesda, Maryland 20892.

Annals of the New York Academy of Sciences
|January 1, 1989
PubMed
Summary
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Noninvasive imaging offers objective insights into microcirculatory pathophysiology, potentially revising sickle cell disease paradigms. These methods precisely quantify disease severity and track therapeutic outcomes, supplementing traditional evaluations.

Area of Science:

  • Medical Imaging
  • Hematology
  • Pathophysiology

Background:

  • Traditional sickle cell disease evaluations may lack objective microcirculatory data.
  • Existing pathophysiologic paradigms may not fully capture disease complexity.

Purpose of the Study:

  • To highlight the role of noninvasive imaging in understanding sickle cell disease microcirculatory pathophysiology.
  • To discuss the potential of these techniques to refine disease assessment and treatment monitoring.

Main Methods:

  • Utilizing advanced noninvasive imaging modalities.
  • Applying sequential application of imaging techniques for longitudinal assessment.

Main Results:

  • Objective data on microcirculatory pathophysiology is now obtainable.

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  • Noninvasive imaging enables more precise, quantitative definition of disease severity.

    • Conclusions:

    • Noninvasive imaging necessitates reevaluation of current sickle cell disease paradigms.
    • These techniques serve as valuable supplements for precise disease monitoring and unambiguous assessment of therapeutic efficacy.