Related Experiment Video
Updated: Mar 28, 2026

07:44
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
3.6K
Macular Surgery Using Intraoperative Spectral Domain Optical Coherence Tomography
Mohammad Riazi-Esfahani1, Mohammad Reza Khademi1, Mehdi Mazloumi1
1Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Journal of Ophthalmic & Vision Research
|January 6, 2016
Summary
Intraoperative spectral domain optical coherence tomography (SD-OCT) allows surgeons to monitor macular anatomy changes during surgery for conditions like macular hole (MH), epiretinal membrane (ERM), and vitreomacular traction (VMT). This real-time imaging aids in achieving better surgical outcomes.
Area of Science:
- Ophthalmology
- Surgical Innovation
- Medical Imaging
Background:
- Macular surgery, including procedures for macular hole (MH), epiretinal membrane (ERM), and vitreomacular traction (VMT), requires precise anatomical assessment.
- Real-time monitoring of intraoperative changes can potentially improve surgical precision and patient outcomes.
Purpose of the Study:
- To evaluate the utility of intraoperative spectral domain optical coherence tomography (SD-OCT) in detecting anatomical alterations during macular surgery.
- To assess the impact of surgical manipulations on macular dimensions and retinal thickness.
Main Methods:
- A consecutive case series of 32 eyes undergoing pars plana vitrectomy with intraoperative SD-OCT.
- Measurements of retinal thickness and macular hole dimensions were performed using a handheld SD-OCT device.
- Analysis included patients with MH, ERM, and VMT.
Main Results:
- Macular hole apex diameter significantly decreased after internal limiting membrane (ILM) peeling (P=0.025).
- Retinal thickness significantly decreased after ERM removal (P=0.018), though this was not sustained.
- Subretinal fluid formation was observed in three ERM cases and two VMT cases after ILM peeling.
Conclusions:
- Intraoperative SD-OCT provides surgeons with immediate feedback on macular anatomical changes.
- This real-time imaging capability may lead to improved anatomical and visual results in macular surgery.

