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Measurement of Heme Synthesis Levels in Mammalian Cells
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Heme metabolism in stress regulation and protein production: From Cinderella to a key player

J L Martínez1,2, D Petranovic1,2, J Nielsen1,2,3

  • 1a Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology , Gothenburg , Sweden.

Bioengineered
|January 6, 2016
PubMed

Heme biosynthesis is a highly conserved pathway which is present in all kingdoms, from Archaea to higher organisms such as plants and mammals. The heme molecule acts as a prosthetic group for different proteins and enzymes involved in energy metabolism and reactions involved in electron transfer. Based on our recent findings and other recent reports, we here illustrate that heme is more than a co-factor. We also discuss the necessity to gain more insight into the heme biosynthesis pathway regulation, as this interacts closely with overall stress control. Understanding heme biosynthesis and its regulation could impact our ability to develop more efficient yeast cell factories for heterologous protein production.

Keywords:
Hap1cell stressheme biosynthesisprotein productionyeast cell factories

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