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Au nanoparticle-based sensor for apomorphine detection in plasma.

Chiara Zanchi1, Andrea Lucotti2, Matteo Tommasini2

  • 1Dipartimento di Energia, Politecnico di Milano, Via Ponzio 34/3, 20133 Milano, Italy.

Beilstein Journal of Nanotechnology
|January 7, 2016
PubMed
Summary
This summary is machine-generated.

Researchers developed nanostructured gold surfaces for detecting apomorphine, a Parkinson's disease drug. This novel sensor shows promise for clinical applications, including detection in human blood plasma.

Keywords:
Au NPsSERSapomorphinenano-roughened filmspulsed laser depositionself-assembled films

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Area of Science:

  • Nanotechnology and Materials Science
  • Analytical Chemistry
  • Biomedical Sensing

Background:

  • Apomorphine is a critical drug for Parkinson's disease treatment.
  • Accurate and sensitive detection of apomorphine is essential for clinical management.
  • Existing detection methods may lack the sensitivity or practicality for real-time clinical use.

Purpose of the Study:

  • To develop and optimize artificially roughened gold surfaces as sensors for apomorphine detection.
  • To investigate the sensor's performance in clinically relevant concentration ranges.
  • To evaluate the sensor's applicability for detecting apomorphine in biological samples like human blood plasma.

Main Methods:

  • Fabrication of nanostructured gold surfaces using pulsed laser deposition.
  • Optimization of sensor parameters using aqueous apomorphine solutions (3.3 × 10⁻⁷ M to 3.3 × 10⁻⁴ M).
  • Utilizing surface-enhanced Raman scattering (SERS) with specific apomorphine peaks for detection.
  • Testing sensor performance with unfiltered human blood plasma.

Main Results:

  • Successfully optimized nanostructured gold surfaces for apomorphine sensing.
  • Established a dynamic concentration range for apomorphine detection using SERS.
  • Demonstrated the sensor's capability to detect apomorphine in unfiltered human blood plasma.

Conclusions:

  • Artificially roughened gold surfaces are effective SERS substrates for apomorphine detection.
  • The developed sensor demonstrates potential for sensitive and specific apomorphine monitoring in clinical settings.
  • This technology offers a promising avenue for real-time therapeutic drug monitoring of apomorphine.