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Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
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Published on: June 14, 2019

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HPV-p53-miR-34a axis in HPV-associated cancers

Jiezhong Chen1, Kong-Nan Zhao1

  • 11 School of Biomedical Sciences, The University of Queensland, St Lucia, QLD 4072, Australia ; 2 Institute of Molecular Virology and Immunology, Department of Medical Microbiology and Immunology, Wenzhou Medical University, Wenzhou 325000, China ; 3 Centre for Kidney Disease Research-Venomics Research, School of Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Brisbane, QLD 4102, Australia.

Annals of Translational Medicine
|January 7, 2016
PubMed
Summary

Human papillomaviruses (HPVs) drive cancer by disrupting cell pathways. This review highlights how miR-34a, a microRNA, is crucial in HPV-associated cancers, impacting cell growth and survival.

Keywords:
E6 oncogeneNotch pathwaySnailcyclin D1epithelial-mesenchymal transition (EMT)proliferation

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