ASSOCIATION AMONG HISTOLOGICAL FINDINGS SUGGESTIVE OF PAPILLOMA VIRUS ON HEMORRHOIDECTOMY SPECIMENS
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Updated: Mar 27, 2026
RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
Soraya Souto da Silva1, Gerson Suguiyama Nakajima1, Ricardo Alexandre Guimarães1
1Getúlio Vargas University Hospital, Federal University of Amazonas, Manaus, AM, Brazil.
Background:
Many researchers studied human Papillomavirus infection in the anal area supposing it represents a risk factor for precursor lesions of anal cancer.
Aim:
To study the association between histological findings suggestive of injury by the virus in hemorrhoidectomy specimens.
Method:
Prevalence study was carried out based on histopathological analysis of hemorrhoidectomy specimens to find viral cytopathic effects. These findings were compared with anal condyloma acuminata that had no relationship with hemorrhoidectomy for microscopic comparison.
Results:
Of the 91 hemorroidectomies analyzed, eight had findings suggestive of viral cytopathic effects, with the presence of irregular acanthosis in 63%, koilocytes in 50% and other indirect viral cytopathic effects, such as hyperkeratosis (38%), parakeratosis (25% ) and papillomatosis (13%).
Conclusion:
This study was unable to conclude that there is an association between these two pathologic entities.
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