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Systemic lupus erythematosus and Raynaud's phenomenon
Flavia Emilie Heimovski1, Juliana A Simioni1, Thelma Larocca Skare1
1Faculdade Evangélica do Paraná, Curitiba, PR, Brazil.
Anais Brasileiros De Dermatologia
|January 7, 2016
Summary
Systemic lupus erythematosus patients with Raynaud's phenomenon are associated with specific antibodies and fewer severe symptoms. This suggests a distinct, potentially milder, clinical subgroup within the disease.
Area of Science:
- Rheumatology
- Immunology
- Clinical Medicine
Background:
- Systemic lupus erythematosus (SLE) presents with diverse clinical and serological subgroups.
- Genetic factors are implicated in the heterogeneity of SLE manifestations.
Purpose of the Study:
- To investigate differences between Brazilian SLE patients with and without Raynaud's phenomenon (RP).
Main Methods:
- Retrospective analysis of 373 SLE patient medical records.
- Comparative analysis of demographic, clinical, and serological data between patients with and without RP.
Main Results:
- Raynaud's phenomenon showed positive associations with older age at diagnosis, anti-Sm antibodies, and anti-RNP antibodies.
- Negative associations were observed between RP and hemolysis, serositis, glomerulonephritis, and IgM aCL antibodies.
Conclusions:
- SLE patients with Raynaud's phenomenon represent a distinct subgroup.
- This subgroup appears to exhibit a milder spectrum of clinical manifestations in SLE.
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