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Published on: December 4, 2020
Recurrent Hemolytic and Uremic Syndrome Induced by Escherichia Coli
Morgane Commereuc1, Francois-Xavier Weill, Estelle Loukiadis
1From the APHP, Hôpital Tenon (MC, RK, CR, ER, AH), Urgences Néphrologiques et Transplantation Rénale, Institut Pasteur (F-XW, MG), Unité des Bactéries Pathogènes Entériques, Centre National de Référence des E coli et Shigella, Paris, VetAgro Sup (EL, AG), Campus vétérinaire de Lyon, Laboratoire d'études des microorganismes alimentaires pathogènes (LMAP), Laboratoire National de Référence pour les E coli y compris les E coli producteurs de Shiga-toxines (LNR STEC), Marcy L'Etoile, Service d'Immunologie, Hôpital Européen Georges Pompidou (VF-B); and UPMC Sorbonne Université Paris 06 (ER, AH), Paris, France.
Abstract:
A widespread belief is that typical hemolytic and uremic syndrome (HUS) does not recur. We report the case of a patient infected twice with raw milk taken from his own cow and containing a Shiga toxin-producing Escherichia coli O174:H21 that induced recurrent HUS causing severe renal and cerebral disorders. A genomic comparison of the human and bovine Shiga toxin-producing Escherichia coli O174:H21 isolates revealed that they were identical. Typical HUS may recur. Since milk from this animal was occasionally distributed locally, thereby posing a serious threat for the whole village, this particular cow was destroyed.
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