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Amiodarone and the thyroid.

R L Kennedy1, H Griffiths, T A Gray

  • 1Department of Medicine, Northern General Hospital, Sheffield, U.K.

Clinical Chemistry
|September 1, 1989
PubMed
Summary
This summary is machine-generated.

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Amiodarone, an antiarrhythmic medication, can disrupt thyroid function due to its high iodine content and interference with thyroid hormone metabolism. This can lead to hypothyroidism or hyperthyroidism in patients.

Area of Science:

  • Endocrinology
  • Pharmacology
  • Cardiology

Background:

  • Amiodarone is an antiarrhythmic drug containing 37% iodine by weight.
  • It shares structural similarities with thyroid hormones.
  • Amiodarone's impact on thyroid hormone levels and function is a significant clinical concern.

Purpose of the Study:

  • To investigate the effects of amiodarone on thyroid hormone metabolism and thyroid function.
  • To understand the mechanisms by which amiodarone induces thyroid dysfunction.
  • To highlight the incidence of hypothyroidism and hyperthyroidism in patients treated with amiodarone.

Main Methods:

  • The study likely involved analysis of patient data and thyroid hormone levels.
  • Assessment of hepatic 5 -deiodinase activity was a key component.

Related Experiment Videos

  • Evaluation of thyroid hormone concentrations (thyroxine and triiodothyronine) in serum.

    • Main Results:

    • Amiodarone inhibits hepatic 5 -deiodinase, altering thyroid hormone levels.
    • Increased serum thyroxine and "reverse" triiodothyronine were observed.
    • Decreased serum triiodothyronine concentrations were noted, alongside a significant incidence of hypothyroidism or hyperthyroidism.

    Conclusions:

    • Amiodarone-induced thyroid dysfunction is primarily due to released iodine and potential unmasking of autoimmune thyroid disease.
    • The drug may interfere with thyroid hormone action at the cellular level, causing localized hypothyroidism.
    • Clinicians should monitor thyroid function in patients receiving amiodarone therapy.