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A novel pseudo resistor structure for biomedical front-end amplifiers.

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    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |January 7, 2016
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    This study introduces a novel pseudo resistor for biomedical front-end amplifiers, improving bandwidth and performance. The new design successfully recorded electrocorticography signals in animal models.

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    Area of Science:

    • Electronics Engineering
    • Biomedical Engineering
    • Signal Processing

    Background:

    • Biomedical front-end amplifiers (FEAs) require efficient and stable components for accurate signal acquisition.
    • Existing pseudo resistor designs may limit the performance of FEAs in terms of bandwidth and distortion.

    Purpose of the Study:

    • To propose and evaluate a novel pseudo resistor structure with tunable DC bias voltage for biomedical FEAs.
    • To compare the performance of the proposed pseudo resistor against existing types in an FEA circuit.

    Main Methods:

    • Design and fabrication of a novel pseudo resistor using a standard TSMC 0.35 μm CMOS process.
    • Implementation of a high-pass filter within the FEA using a differential difference amplifier and the proposed pseudo resistor.
    • Simulation, fabrication, and measurement of three types of FEAs with different pseudo resistors.
    • Electrocorticography (ECoG) signal recording in an in vivo rat model.

    Main Results:

    • The proposed pseudo resistor demonstrated superior bandwidth compared to two other types.
    • The implemented high-pass filter exhibited cutoff frequencies of 0.15 Hz and 4.98 KHz.
    • Achieved low total harmonic distortion (-58 dB at 1 kHz) and high stability across a wide supply and control voltage range.
    • Successfully recorded ECoG spike-and-wave discharges in rats.

    Conclusions:

    • The novel pseudo resistor offers enhanced performance for biomedical FEAs, particularly in bandwidth and stability.
    • The proposed design is suitable for high-fidelity ECoG signal acquisition, as validated by in vivo experiments.