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Related Experiment Video

Updated: Mar 27, 2026

Multimodal 3D Printing of Phantoms to Simulate Biological Tissue
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Multimodal 3D Printing of Phantoms to Simulate Biological Tissue

Published on: January 11, 2020

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Manufacturing of microcirculation phantoms using rapid prototyping technologies.

Anthony Buchoux, Prashant Valluri, Stewart Smith

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |January 7, 2016
    PubMed
    Summary

    Researchers developed a novel microcirculation phantom for studying blood flow dynamics with optical methods. This 3D printed phantom, made using Acrylonitrile Butadiene Styrene and Polydimethylsiloxane, aids in testing advanced medical imaging technologies.

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    Last Updated: Mar 27, 2026

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    Area of Science:

    • Biomedical Engineering
    • Optical Imaging
    • Fluid Dynamics

    Background:

    • Investigating microcirculation hemodynamics is crucial for understanding various physiological and pathological processes.
    • Current methods for studying microcirculation often face limitations in resolution, scalability, or mimicking in vivo conditions.
    • Developing advanced phantoms is essential for validating new optical imaging techniques and diagnostic tools.

    Purpose of the Study:

    • To describe a novel method for fabricating a microcirculation phantom.
    • To enable the investigation of hemodynamics using optics-based methods.
    • To provide a tool for testing and validating medical imaging technologies.

    Main Methods:

    • Fabrication of a negative mold using Acrylonitrile Butadiene Styrene (ABS) via Fused Deposition Modeling (FDM) printing.
    • Embedding the ABS mold in Polydimethylsiloxane (PDMS) to create the phantom structure.
    • Dissolving the internal ABS mold using acetone to form a hollow microchannel network.
    • Testing the phantom's functionality using red blood cell (RBC) analogues.

    Main Results:

    • Successfully manufactured an enlarged three-dimensional (3D) network mimicking microcirculation.
    • Demonstrated the phantom's capability to be used with optical methods for hemodynamic studies.
    • Validated the phantom's utility for testing medical imaging technology.

    Conclusions:

    • The described method provides an effective way to create a microcirculation phantom.
    • This phantom serves as a valuable platform for optical investigation of hemodynamics.
    • The developed phantom has significant potential for advancing medical imaging technology development and testing.