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A compound ampoule for large-volume controllable jet injection.

Bryan P Ruddy, James W Mckeage, Rhys M J Williams

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |January 7, 2016
    PubMed
    Summary

    This study introduces a novel needle-free injector ampoule with a dual-piston design for controlled drug delivery. The innovative ampoule enables precise injection of large volumes to specific tissue depths.

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    Area of Science:

    • Biomedical Engineering
    • Drug Delivery Systems
    • Medical Device Design

    Background:

    • Conventional needle-based drug delivery faces limitations in administering large volumes and controlling injection depth.
    • Existing needle-free injection technologies struggle with precise depth control and handling larger volumes.
    • There is a need for advanced drug delivery devices capable of accurate, needle-free administration of therapeutics.

    Purpose of the Study:

    • To present a novel needle-free injector ampoule design utilizing a dual-piston mechanism.
    • To enable controlled, needle-free delivery of relatively large fluid volumes to specific tissue depths.
    • To overcome limitations of conventional ampoules and actuators in precise drug administration.

    Main Methods:

    • A new needle-free injector ampoule design featuring two concentric pistons was conceptualized and constructed.

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  • The ampoule's fluid pressurization and jet velocity characteristics were analyzed using a dual-phase injection approach.
  • Performance was evaluated through free-air jet velocity measurements and injections into post-mortem porcine tissue models.

    • Main Results:

    • The developed 1.2mL ampoule successfully generated two distinct injection phases: a high-velocity piercing jet followed by a low-velocity delivery jet.
    • A smooth transition in jet velocity was observed as the inner and outer pistons engaged during operation.
    • Injections demonstrated penetration of porcine skin to controlled depths, delivering fluid to subcutaneous and/or intramuscular layers.

    Conclusions:

    • The novel dual-piston ampoule design facilitates needle-free delivery of substantial fluid volumes to targeted tissue depths.
    • The device offers a promising alternative to conventional methods for controlled drug administration.
    • Further research is necessary to optimize fluid retention at the desired depth within the tissue.