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A Free-breathing fMRI Method to Study Human Olfactory Function
Published on: July 30, 2017
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An extension of olfactometry methods: An expandable, fully automated, mobile, MRI-compatible olfactometer
Anne-Kathrin Bestgen1, Patrick Schulze2, Lars Kuchinke1
1Department of Psychology, Ruhr-University Bochum, Universitätsstraße 150, 44801 Bochum, Germany.
Journal of Neuroscience Methods
|January 8, 2016
Summary
This study introduces an improved 24-channel olfactometer for functional magnetic resonance imaging (fMRI) studies. The new design offers precise odor delivery, enhancing the study of olfactory cognition in MR environments.
Area of Science:
- Neuroscience
- Sensory Perception
Background:
- Functional magnetic resonance imaging (fMRI) offers novel insights into olfactory cognition, a complex and understudied sensory system.
- Conducting fMRI experiments on olfaction presents significant technical challenges.
Purpose of the Study:
- To present an innovative and cost-effective 24-channel olfactometer designed for fMRI studies.
- To overcome the limitations of existing olfactometers in MR environments.
Main Methods:
- The design incorporates pneumatically controlled pinch valves for precise stimulus timing within the scanner.
- Features include a 3D-printed nasal mask inlet for lateralized stimulus presentation and common sleep masks.
- A flexible Matlab code and portable container system enable a fully automated and mobile setup.
Main Results:
- Functional efficiency was validated through an fMRI study.
- Temporal resolution and concentration stability were confirmed using mass spectrometry.
Conclusions:
- The presented olfactometer design is a practical and viable solution for olfactory stimulus presentation in MR settings.
- It offers an affordable alternative with fast onset times, lateralized presentation, and high adaptability.
