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Long-Term Mortality and Its Risk Factors in Stroke Survivors

Sara Maria Mathisen1, Ingvild Dalen2, Jan Petter Larsen2

  • 1Department of Neurology, Stavanger University Hospital, Stavanger, Norway; The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway; Neuroscience Research Group, Stavanger University Hospital, Stavanger, Norway.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|January 8, 2016
PubMed

Insights

Long-term mortality after stroke is significantly higher than in stroke-free individuals. Low cholesterol, hemoglobin, high homocysteine, and elevated creatinine are key predictors of increased stroke mortality.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Public Health

Background:

  • Stroke is a leading global cause of death.
  • Understanding stroke mortality risk factors is crucial for patient care.
  • Limited research exists on long-term mortality post-stroke.

Purpose of the Study:

  • To investigate long-term mortality in acute stroke patients.
  • To identify predictive risk factors for long-term mortality after stroke.

Main Methods:

  • A cohort of 1137 acute stroke patients was compared to a matched stroke-free control group.
  • Long-term follow-up extended up to 16.4 years.
  • Demographic, clinical, and hematological factors were analyzed for their effect on mortality in 1018 patients.

Main Results:

  • Stroke patients had a significantly higher mortality rate (51.7%) compared to controls (32.7%) over the study period (HR 2.2).
  • At 12 years, 72.5% of stroke patients and 53% of controls had died.
  • Independent predictors of increased long-term mortality included age, diabetes, stroke severity, low cholesterol, low hemoglobin, hyperhomocysteinemia, and elevated serum creatinine.

Conclusions:

  • Patients surviving the acute phase of stroke face substantially increased long-term mortality.
  • Monitoring creatinine, homocysteine, and hemoglobin levels post-stroke is recommended for improved patient management.
Abstract

Keywords:
Strokecreatininehomocysteinelong-termmortalityrisk factors

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