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Updated: Mar 27, 2026

Quantifying the Antifungal Activity of Peptides Against Candida albicans
Published on: January 13, 2023
Antifungal Agents: Spectrum of Activity, Pharmacology, and Clinical Indications
Jeniel E Nett1, David R Andes1
1Department of Medicine, University of Wisconsin, Madison, WI 53705, USA; Department of Medical Microbiology & Immunology, University of Wisconsin, Madison, WI 53705, USA.
Abstract:
The currently available antifungal therapies vary significantly in terms of spectrum of activity, pharmacologic properties, toxicity, and potential for drug-drug interactions. This article provides a history of antifungal development and discusses the characteristics of individual drugs and drug classes, including the amphotericin B formulations, the triazoles, the echinocandins, and flucytosine. For each drug, the clinically relevant pharmacokinetics are reviewed, the spectrum of activity described, and the Food and Drug Administration-approved clinical indications examined. Antifungal side-effects, therapeutic drug monitoring, and drug-drug interactions are summarized. The variations among different formulations are highlighted.
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