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Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging
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Invasive Candidiasis.

Todd P McCarty1, Peter G Pappas1

  • 1University of Alabama at Birmingham, 1900 University Boulevard, 229 THT, Birmingham, AL 35294-0006, USA.

Infectious Disease Clinics of North America
|January 8, 2016
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Summary
This summary is machine-generated.

Invasive candidiasis, including candidemia, involves Candida species infections. Understanding species-specific factors guides antifungal therapy and treatment duration, with molecular diagnostics improving patient care.

Keywords:
AntifungalsBloodstream infectionCandidaFungal infectionInvasive candidiasis

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Clinical Diagnostics

Background:

  • Invasive candidiasis encompasses syndromes caused by Candida species, with candidemia being the most frequent.
  • Five Candida species are responsible for the majority of invasive infections.
  • Clinical scenarios can influence the predominant Candida species, impacting treatment decisions.

Purpose of the Study:

  • To highlight the clinical significance of different Candida species in invasive infections.
  • To emphasize the importance of species identification for guiding antifungal therapy and treatment duration.
  • To underscore the growing role of molecular diagnostics in managing invasive candidiasis.

Main Methods:

  • Review of clinical literature on invasive candidiasis and candidemia.
  • Discussion of factors influencing Candida species distribution.
  • Evaluation of the role of traditional and molecular diagnostic methods.

Main Results:

  • Species identification is crucial for selecting appropriate antifungal agents and determining treatment length.
  • Molecular diagnostic technologies offer advantages over traditional methods for rapid and accurate detection.
  • Early and accurate diagnosis can lead to improved patient outcomes.

Conclusions:

  • Accurate identification of Candida species is essential for effective management of invasive candidiasis.
  • Molecular diagnostics represent a significant advancement in the timely diagnosis and treatment of these infections.
  • Optimizing antifungal therapy based on species-specific data improves patient care and reduces treatment complications.