Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A chronic intracortical electrode array: preliminary results.

P K Campbell1, R A Normann, K W Horch

  • 1Department of Bioengineering, University of Utah, Salt Lake City 84112.

Journal of Biomedical Materials Research
|August 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Walking-related knee contact forces and associations with knee pain across people with mild, moderate and severe radiographic knee osteoarthritis: a cross-sectional study.

Osteoarthritis and cartilage·2022
Same author

Development of a core capability framework for qualified health professionals to optimise care for people with osteoarthritis: an OARSI initiative.

Osteoarthritis and cartilage·2019
Same author

Mechanical fatigue resistance of an implantable branched lead system for a distributed set of longitudinal intrafascicular electrodes.

Journal of neural engineering·2017
Same author

Moderators and mediators of effects of unloading shoes on knee pain in people with knee osteoarthritis: an exploratory analysis of the SHARK randomised controlled trial.

Osteoarthritis and cartilage·2017
Same author

Associations between changes in knee pain location and clinical symptoms in people with medial knee osteoarthritis using footwear for self-management: an exploratory study.

Osteoarthritis and cartilage·2017
Same author

The knee adduction moment and knee osteoarthritis symptoms: relationships according to radiographic disease severity.

Osteoarthritis and cartilage·2016
Same journal

Optimizing the tensile properties of polyvinyl alcohol hydrogel for the construction of a bioprosthetic heart valve stent.

Journal of biomedical materials research·2002
Same journal

Wear of conventional and cross-linked ultra-high-molecular-weight polyethylene acetabular cups against polished and roughened CoCr femoral heads in a biaxial hip simulator.

Journal of biomedical materials research·2002
Same journal

Immobilization of natural macromolecules on poly-L-lactic acid membrane surface in order to improve its cytocompatibility.

Journal of biomedical materials research·2002
Same journal

Light scattering and in vitro biocompatibility studies of poly (vinyl pyrrolidone) derivatives with amino-acid-dependent groups.

Journal of biomedical materials research·2002
Same journal

Immobilization of an oxalate-degrading enzyme on silicone elastomer.

Journal of biomedical materials research·2002
Same journal

An evaluation of the cytotoxic effects of orthodontic bonding adhesives upon a primary human oral gingival fibroblast culture and a permanent, human oral cancer-cell line.

Journal of biomedical materials research·2002
See all related articles

Developing chronic intracortical stimulating electrode arrays requires balancing electrode stiffness for stable spacing and lead flexibility to prevent movement. This research compared two array designs for optimal neural stimulation performance.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Chronic intracortical electrical stimulation is crucial for advanced neural prosthetics.
  • Optimizing electrode array design is essential for long-term efficacy and minimizing neural damage.

Purpose of the Study:

  • To evaluate the performance and implantation challenges of two chronic intracortical electrode array designs with different electrode diameters (25- and 50-microns).
  • To identify key design properties for future intracortical stimulating electrode arrays.

Main Methods:

  • Development of two electrode array prototypes using platinum-iridium wires (25- and 50-microns diameter) insulated with Teflon.
  • Acute and chronic implantation studies in feline cortical tissue.
  • Histological analysis to assess neural damage and interelectrode spacing changes.

Related Experiment Videos

Main Results:

  • Arrays with 50-micron electrodes maintained spacing but exhibited implantation difficulties due to lead stress.
  • Arrays with 25-micron electrodes were easier to implant but showed altered interelectrode spacing.
  • Both configurations experienced post-implantation movement, indicating a need for improved mechanical stability.

Conclusions:

  • Future chronic intracortical stimulating electrode arrays require stiff penetrating electrodes and substrates to preserve interelectrode spacing.
  • Extremely flexible percutaneous leads are necessary to prevent array movement post-implantation.
  • A balance between stiffness for stability and flexibility for maneuverability is key for effective neural stimulation device design.