Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

379
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
379
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

281
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
281
Metabolic States of the Body: The Postabsorptive State01:18

Metabolic States of the Body: The Postabsorptive State

1.6K
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
1.6K
Obesity01:24

Obesity

1.5K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.5K
Metabolic States of the Body: Fasting and Starvation01:24

Metabolic States of the Body: Fasting and Starvation

3.3K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
3.3K
Gastric Emptying01:16

Gastric Emptying

4.9K
Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

En-bloc lung transplantation: Rare but useful.

JTCVS techniques·2026
Same author

Interleukin-1-mediated inflammatory memory: Protective training or maladaptive tumor imprinting?

Seminars in immunology·2026
Same author

The Global Burden of Human Metapneumovirus in High-Risk Adults: A Systematic Literature Review and Meta-Analysis.

Journal of epidemiology and global health·2026
Same author

High-dose Olanzapine Versus Clozapine in Treatment-resistant Schizophrenia: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Journal of psychiatric practice·2026
Same author

Translabyrinthine versus middle fossa approaches for vestibular schwannoma surgery: a systematic review and comparative meta-analysis.

Neuro-Chirurgie·2026
Same author

Comparative diagnostic performance of artificial intelligence models in structural MRI for schizophrenia: A systematic review and meta-analysis.

Asian journal of psychiatry·2025

Related Experiment Video

Updated: Mar 27, 2026

Roux-en-Y Gastric Bypass Operation in Rats
07:37

Roux-en-Y Gastric Bypass Operation in Rats

Published on: June 11, 2012

24.5K

Metabolic Changes After Roux-N-Y Bariatric Surgery In Hispanics.

José Hernández-Gil de Lamadrid, Juan J Nieves-Rivera, Laura Mora

    Boletin De La Asociacion Medica De Puerto Rico
    |January 9, 2016
    PubMed
    Summary
    This summary is machine-generated.

    Bariatric surgery significantly improved metabolic health in obese Hispanic patients, reducing BMI, lipids, and blood sugar. Weight loss alone doesn't fully explain these positive outcomes.

    More Related Videos

    A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers
    11:58

    A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers

    Published on: August 21, 2021

    6.1K
    Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
    10:05

    Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

    Published on: March 20, 2017

    12.9K

    Related Experiment Videos

    Last Updated: Mar 27, 2026

    Roux-en-Y Gastric Bypass Operation in Rats
    07:37

    Roux-en-Y Gastric Bypass Operation in Rats

    Published on: June 11, 2012

    24.5K
    A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers
    11:58

    A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers

    Published on: August 21, 2021

    6.1K
    Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
    10:05

    Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

    Published on: March 20, 2017

    12.9K

    Area of Science:

    • Metabolic Surgery
    • Obesity Medicine
    • Bariatric Surgery Outcomes

    Background:

    • Morbid obesity presents significant health challenges, particularly in Hispanic populations.
    • Bariatric surgery is a key intervention for managing severe obesity and its comorbidities.
    • Roux-en-Y gastric bypass is a common bariatric procedure with known metabolic benefits.

    Purpose of the Study:

    • To assess metabolic outcomes 12 months post-bariatric surgery in morbidly obese Hispanic patients.
    • To evaluate the correlation between weight loss and metabolic improvements.
    • To identify potential non-weight-related mechanisms driving metabolic changes.

    Main Methods:

    • Retrospective analysis of 102 morbidly obese Hispanic patients undergoing bariatric surgery.
    • Data collection included Body Mass Index (BMI), weight, lipid profile (TC, HDL, LDL, triglycerides), and fasting blood sugar (FBS) pre- and post-surgery.
    • Statistical analysis to determine significant changes and correlation with weight loss.

    Main Results:

    • Roux-en-Y gastric bypass was performed in 97% of patients.
    • Significant reductions observed in BMI (-14.3 kg/m2), weight (-86.1 lbs), total cholesterol (-17.9 mg/dL), triglycerides (-28.7 mg/dL), LDL (-15.4 mg/dL), and FBS (-11.3 mg/dL).
    • HDL levels increased by +5.22 mg/dL. A weak correlation was found between weight loss and these metabolic improvements.

    Conclusions:

    • Roux-en-Y gastric bypass surgery leads to significant improvements in lipid profiles and fasting blood sugar levels in obese Hispanic patients.
    • Metabolic improvements observed extend beyond what can be attributed solely to weight loss.
    • Further research is needed to elucidate the independent mechanisms driving these metabolic changes post-bariatric surgery.