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Related Experiment Video

Updated: Mar 27, 2026

CO2-Lasertonsillotomy Under Local Anesthesia in Adults
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Of grave concern.

Clare L Fraser1, Simon Taylor1, Kate Reid2

  • 1Department of Ophthalmology, Macquarie University Hospital, Sydney, Australia; Save Sight Institute, Department of Ophthalmology, Faculty of Medicine, University of Sydney, Australia.

Survey of Ophthalmology
|January 9, 2016
PubMed
Summary
This summary is machine-generated.

A patient developed Creutzfeldt-Jakob disease (CJD) after orbital decompression surgery for thyroid eye disease. This rare neurological disorder caused rapid vision loss and cognitive decline.

Keywords:
Creutzfeldt-Jacob diseaseHeidenhain variantcompressive optic neuropathyhigher visual processingproptosisspongiform encephalopathythyroid eye diseasevisual fields

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Area of Science:

  • Neurology
  • Ophthalmology

Background:

  • Thyroid eye disease (TED) can necessitate surgical intervention like orbital decompression.
  • Post-decompression complications require careful differential diagnosis.

Observation:

  • A 73-year-old woman experienced vision loss and proptosis weeks after orbital decompression.
  • She developed cognitive decline, metamorphopsia, and insomnia.
  • Neurological examination revealed visual processing deficits and memory problems.

Findings:

  • Neuroimaging showed occipital cortical ribboning.
  • Cerebrospinal fluid tested positive for 14-3-3 protein.
  • Electroencephalogram demonstrated periodic complexes, indicative of Creutzfeldt-Jakob disease (Heidenhain variant).

Implications:

  • This case highlights a rare presentation of Creutzfeldt-Jakob disease mimicking orbital decompression complications.
  • Early recognition of neurological symptoms is crucial for accurate diagnosis.
  • Highlights the importance of considering prion diseases in atypical neurological presentations post-surgery.