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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Cytomegalovirus Infection in Pediatric Solid Organ Transplant Recipients: a Focus on Prevention

Karen C Tsai1, Lara A Danziger-Isakov2, David B Banach3

  • 1Yale School of Medicine, 800 Howard Avenue, New Haven, CT, USA. Karen.Tsai@yale.edu.

Current Infectious Disease Reports
|January 9, 2016
PubMed

Insights

Cytomegalovirus (CMV) infection is common after pediatric solid organ transplantation. This review examines current and novel strategies for CMV prevention, including prophylaxis and preemptive therapy, to improve outcomes.

Area of Science:

  • Pediatric Solid Organ Transplantation
  • Infectious Diseases
  • Immunology

Background:

  • Solid organ transplantation offers life-saving treatment for pediatric end-stage organ disease.
  • Cytomegalovirus (CMV) infection is a significant post-transplant complication in children.
  • Current CMV prevention standards in pediatric transplantation lack clarity.

Purpose of the Study:

  • To review the literature on Cytomegalovirus (CMV) in pediatric solid organ transplantation.
  • To discuss current and novel CMV prevention strategies.
  • To inform the standard of care for CMV management in this population.

Main Methods:

  • Comprehensive literature review of CMV in pediatric solid organ transplantation.
  • Analysis of CMV disease effects, risk factors, diagnostics, and treatments.
  • Focus on prophylaxis, preemptive, and hybrid prevention strategies.

Main Results:

  • Cytomegalovirus (CMV) is a prevalent post-transplant infection in pediatric solid organ transplant recipients.
  • Various prevention strategies exist, including prophylaxis, preemptive therapy, and hybrid approaches.
  • Novel strategies are being explored to enhance CMV prevention efficacy.

Conclusions:

  • Optimizing Cytomegalovirus (CMV) prevention is crucial for improving outcomes in pediatric solid organ transplant recipients.
  • A clear standard of care for CMV prevention in this vulnerable population is needed.
  • Further research into novel prevention methods is warranted.

Keywords:
CMVCytomegalovirusHybridPediatricPreemptiveProphylaxisSolid organ transplantation

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