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Laryngeal primary malignant melanoma: a case report
Oana Cojocaru1, Mariana Aşchie, Liliana Mocanu
1Department of Pathology, Faculty of Medicine, "Ovidius" University, Clinical Service of Pathology, Emergency County Hospital, Constanta, Romania; aschiemariana@yahoo.com.
Summary
This study reports a rare case of primary laryngeal malignant melanoma in a 53-year-old male smoker. Diagnosis was confirmed via histological and immunohistochemical analysis of an excisional biopsy.
Area of Science:
- Oncology
- Pathology
Background:
- Malignant melanoma of the larynx is exceptionally rare, presenting either as a primary tumor or metastasis.
- Risk factors include smoking, though primary laryngeal melanoma lacks cutaneous lesions.
Observation:
- A 53-year-old male presented with hoarseness and a history of smoking.
- Histological examination revealed a tumor with polygonal-epithelioid and spindle-shaped cells containing melanin.
- In situ malignant melanocytes were identified within the laryngeal epithelium.
Findings:
- Immunohistochemical stains were positive for S-100 protein, HMB-45, and Melan-A.
- Cytokeratin stains were negative, ruling out epithelial origin.
- The diagnosis of primary laryngeal malignant melanoma was established based on clinical and histological evidence.
Implications:
- This case highlights the importance of considering rare diagnoses in head and neck oncology.
- Accurate histological and immunohistochemical analysis is crucial for diagnosing primary laryngeal melanoma.
- Understanding the characteristics of this rare cancer aids in appropriate patient management and further research.
