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Pure Nodal Small Lymphocytic Lymphoma: Clinical, Pathologic, and Outcome Features in a Single-Center Cohort
Andreea Georgiana Stoica1,2,3, Mariana Așchie2,4,5, Miruna Gherase-Cristian2,6
1Faculty of Medicine, "Ovidius" University of Constanta, 900470 Constanta, Romania.
Medicina (Kaunas, Lithuania)
|June 26, 2026
Summary
Pure nodal small lymphocytic lymphoma (SLL) is diverse. Clinical factors like elevated beta-2 microglobulin and advanced stage predict shorter time to treatment and progression in SLL patients.
Area of Science:
- Hematology
- Oncology
- Clinical Research
Background:
- Small lymphocytic lymphoma (SLL) is the tissue manifestation of chronic lymphocytic leukemia (CLL).
- Pure nodal SLL patients are underrepresented in clinical trials.
- Limited data exists on the clinical behavior of pure nodal SLL.
Purpose of the Study:
- Identify factors influencing time to first treatment (TTFT).
- Identify factors influencing progression-only survival in pure nodal SLL.
- Evaluate prognostic impact of clinical, laboratory, and TP53 parameters.
Main Methods:
- Prospective observational study.
- Included 46 patients with pure nodal SLL.
- Median follow-up of approximately 5 years.
Main Results:
- Advanced stage, low hemoglobin, elevated serum β2M, elevated LDH, del(17p), and aberrant p53 expression correlated with shorter TTFT and progression-only survival.
- Elevated β2M (≥3.5 mg/L), bulky lymphadenopathy (≥5 cm), and advanced stage showed significantly shorter TTFT.
Conclusions:
- Pure nodal SLL exhibits heterogeneous clinical courses.
- Clinical and biological parameters, including TP53 abnormalities, aid in predicting treatment needs and progression.
- These factors facilitate risk stratification and personalized management for SLL.
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