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Association between depression and periodontitis: a systematic review and meta-analysis
Milena Moreira Araújo1, Carolina Castro Martins2, Lidiane Cristina Machado Costa1
1Department of Dental Clinics, Oral Pathology, and Oral Surgery, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Journal of Clinical Periodontology
|January 9, 2016
Summary
This systematic review found no significant association between depression and periodontitis. More research is needed to explore this complex relationship in diverse populations.
Area of Science:
- Oral Health Research
- Mental Health Studies
- Epidemiology
Background:
- Depression and periodontitis are prevalent conditions.
- Potential links between mental health and oral health warrant investigation.
Purpose of the Study:
- To systematically review and meta-analyze existing evidence on the association between depression and periodontitis.
Main Methods:
- Conducted a comprehensive electronic and manual search of relevant studies.
- Included 15 studies (8 cross-sectional, 6 case-control, 1 cohort).
- Performed meta-analysis on seven cross-sectional studies using odds ratios.
Main Results:
- Six studies reported an association between depression and periodontitis; nine did not.
- Meta-analysis of cross-sectional studies showed no statistically significant association (OR = 1.03, 95% CI = 0.75-1.41).
- The majority of included studies demonstrated low risk of bias.
Conclusions:
- Significant heterogeneity exists among studies investigating depression and periodontitis.
- The current meta-analysis does not support a definitive association.
- Further research with diverse designs and populations is recommended.
