Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

792
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
792
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

552
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
552
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

955
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
955
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

417
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
417
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.6K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.6K
Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

631
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
631

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex Differences in Coronary Atherosclerotic Phenotype and Healing Pattern on Optical Coherence Tomography Imaging.

Circulation. Cardiovascular imaging·2023
Same author

Body mass index variation in adults with Williams syndrome: associations with predicted dietary intake and food behaviors.

Food & nutrition research·2023
Same author

Serum Oxytocin Levels Decrease 12 Months Following Sleeve Gastrectomy and Are Associated with Decreases in Lean Mass.

International journal of molecular sciences·2023
Same author

Growth Hormone Administration Improves Nonalcoholic Fatty Liver Disease in Overweight/Obesity: A Randomized Trial.

The Journal of clinical endocrinology and metabolism·2023
Same author

Alcohol and opiate misuse in adults with cystic fibrosis.

Pediatric pulmonology·2023
Same author

Randomized Placebo-Controlled Trial to Evaluate Effects of Eplerenone on Myocardial Perfusion and Function Among Persons With Human Immunodeficiency Virus (HIV)-Results From the MIRACLE HIV Study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2023

Related Experiment Video

Updated: Mar 27, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

4.7K

Coronary Calcification and Plaque Vulnerability: An Optical Coherence Tomographic Study.

Daniel S Ong1, Jay S Lee1, Tsunenari Soeda1

  • 1From the Division of Cardiology (D.S.O., J.S.L., T.S., Y.M., Z.W., I.-K.J.) and Biostatistics Center (H.L.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan (T.H., H.Y., T.Y, K.O.); and Division of Cardiology, Kyung Hee University, Seoul, South Korea (I.-K.J.).

Circulation. Cardiovascular Imaging
|January 9, 2016
PubMed
Summary

Spotty superficial calcium deposits in coronary arteries do not differ between patients with acute myocardial infarction and stable angina. This finding suggests coronary calcification patterns may not indicate local plaque vulnerability.

Keywords:
atherosclerosiscalciumcross-sectional studiesmyocardial infarctiontomography, optical coherence

More Related Videos

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

16.3K
Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection
06:57

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection

Published on: September 22, 2023

1.6K

Related Experiment Videos

Last Updated: Mar 27, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

4.7K
Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

16.3K
Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection
06:57

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection

Published on: September 22, 2023

1.6K

Area of Science:

  • Cardiovascular Imaging
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Previous intravascular imaging suggested spotty superficial calcium deposits indicate plaque vulnerability.
  • Biomechanical models link microcalcifications to increased fibrous cap stress and plaque rupture.
  • Limitations in intravascular ultrasound resolution hinder discrimination of single vs. clustered calcifications.

Purpose of the Study:

  • To investigate the role of coronary calcification patterns in plaque vulnerability.
  • To compare calcification characteristics in culprit plaques of ST-segment-elevation myocardial infarction (STEMI) patients with plaque rupture versus stable angina patients.

Main Methods:

  • Detailed optical coherence tomography (OCT) assessment of coronary calcification in 53 STEMI patients and 55 stable angina patients.
  • Analysis of individual calcium deposits (number, length, arc, depth) within a 10-mm culprit plaque segment.
  • Classification of deposits as spotty, large, and superficial based on quantitative parameters.

Main Results:

  • No significant differences in the total number, spotty, or large calcium deposits between STEMI and stable angina groups.
  • Similar minimum calcium depth and number of superficial deposits between the two patient groups.
  • No significant difference in superficial deposit counts using 65-µm or 100-µm depth thresholds.

Conclusions:

  • The number and pattern of culprit plaque calcifications are similar in STEMI with plaque rupture and stable angina.
  • OCT assessment of coronary calcification may not be a reliable marker for local plaque vulnerability.
  • Further research is needed to understand the precise role of calcification in plaque instability.