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Proposed reference sequences for hepatitis E virus subtypes
Donald B Smith1, Peter Simmonds1, Jacques Izopet2
1University of Edinburgh, Centre for Immunity, Infection and Evolution, Edinburgh, Scotland, UK.
The Journal of General Virology
|January 9, 2016
Summary
Inconsistent hepatitis E virus (HEV) nomenclature hinders research. This study proposes standardized genome reference sequences for HEV subtypes to improve clarity and communication among scientists studying this pathogen.
Area of Science:
- Virology
- Genomics
- Infectious Diseases
Background:
- The nomenclature of hepatitis E virus (HEV) subtypes is inconsistent.
- This inconsistency complicates the comparison of findings across different research studies.
Purpose of the Study:
- To propose a standardized system for HEV subtyping.
- To provide a table of proposed complete genome reference sequences for each HEV subtype.
- To facilitate clearer communication and epidemiological studies of HEV.
Main Methods:
- A conservative and pragmatic approach was used for subtype assignment.
- Criteria for subtype assignment were based on variations in genotypes and methodologies.
Main Results:
- A table of proposed complete genome reference sequences for each HEV subtype has been provided.
- The proposed subtyping procedure is intended to be adopted by the scientific community.
Conclusions:
- Standardized HEV reference sequences will improve communication among researchers.
- This standardization will aid in clarifying the epidemiology of HEV.
- The proposed subtyping procedure may be applicable to other viruses within the Orthohepevirus genus.
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