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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Mar 27, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
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Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

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Structural brain alterations in primary open angle glaucoma: a 3T MRI study.

Jieqiong Wang1, Ting Li2, Bernhard A Sabel3

  • 1State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, China.

Scientific Reports
|January 9, 2016
PubMed
Summary
This summary is machine-generated.

Primary open angle glaucoma (POAG) causes brain structure degeneration, affecting visual and non-visual regions. Brain changes in glaucoma patients correlate with disease severity, indicating broader neurological impact.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Medical Imaging

Background:

  • Glaucoma is primarily an optic nerve disease, but emerging evidence suggests associated brain structural changes.
  • Understanding these extra-ocular manifestations is crucial for a comprehensive view of glaucoma's pathology.

Purpose of the Study:

  • To investigate visual and non-visual brain structural alterations in primary open angle glaucoma (POAG) patients.
  • To correlate these brain changes with clinical glaucoma severity parameters.

Main Methods:

  • T1-weighted MRI scans were acquired from 25 POAG patients and 25 healthy controls.
  • Volume-based analysis (VBA), surface-based analysis (SBA), and region-of-interest (ROI) analysis of LGN, V1/2, amygdala, and hippocampus were performed.
  • Correlations between brain structure volumes/thickness and clinical metrics (CDR, visual field mean deviation) were assessed.

Main Results:

  • Surface-based analysis revealed reduced cortical thickness in the right frontal pole.
  • ROI analysis showed significant volume reduction in the bilateral lateral geniculate nucleus (LGN), right V1, and left amygdala.
  • Clinical correlations indicated that LGN and V1 structural changes reflect glaucoma severity.

Conclusions:

  • Primary open angle glaucoma is associated with structural degeneration in both vision-related and non-visual brain areas.
  • Brain structural abnormalities in POAG patients correlate with key clinical indicators of disease severity.
  • These findings highlight the systemic neurological impact of glaucoma beyond the eye.