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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Treatment Resistant Cancers02:56

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Long Non-coding RNAs and Drug Resistance.

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Long non-coding RNAs (lncRNAs) are crucial in gene expression and cancer development. Aberrant lncRNA expression drives drug resistance, hindering cancer therapy and necessitating new treatment strategies.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Long non-coding RNAs (lncRNAs) regulate gene expression and cell development.
  • Aberrant lncRNA expression is linked to cancer and drug resistance.
  • lncRNAs modulate mRNA stability and translation impacting cell survival and drug metabolism.

Purpose of the Study:

  • To review recent advances in lncRNAs associated with drug resistance.
  • To summarize molecular and cellular mechanisms of lncRNA-mediated drug resistance.
  • To explore therapeutic strategies to overcome treatment failure in cancer.

Main Methods:

  • Literature review of studies on lncRNAs and drug resistance.
  • Analysis of molecular mechanisms.
  • Synthesis of cellular pathways involved.

Main Results:

  • lncRNAs play a significant role in the development of cancer drug resistance.
  • Specific lncRNAs modulate key factors for cell survival, proliferation, and drug metabolism.
  • Understanding these mechanisms offers potential therapeutic targets.

Conclusions:

  • lncRNAs are critical regulators in cancer drug resistance.
  • Targeting lncRNAs presents a promising avenue for novel cancer therapies.
  • Further research into lncRNA mechanisms can overcome treatment failure.