Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sutures of the Skull01:22

Sutures of the Skull

14.2K
The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
14.2K
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

15.2K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
15.2K
Fractures: Bone Repair01:27

Fractures: Bone Repair

6.6K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
6.6K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

13.5K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
13.5K
Cranial Bones: Superior and Posterior View01:14

Cranial Bones: Superior and Posterior View

8.6K
The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
8.6K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

2.0K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Attojoule Superconducting Thermal Logic and Memories.

Nano letters·2025
Same author

Deep Mouse Brain Two-Photon Near-Infrared Fluorescence Imaging Using a Superconducting Nanowire Single-Photon Detector Array.

ACS photonics·2024
Same author

Fast time-domain diffuse correlation spectroscopy with superconducting nanowire single-photon detector: system validation and in vivo results.

Scientific reports·2023
Same author

Interstitial null-distance time-domain diffuse optical spectroscopy using a superconducting nanowire detector.

Journal of biomedical optics·2023
Same author

Plastic Surgery Training across Seven Continents: Results from the First Global Trainee Survey.

Plastic and reconstructive surgery. Global open·2022
Same author

International Confederation of Societies of Plastic Surgery Trainees: Connecting and Empowering Plastic Surgery Trainees Worldwide.

Plastic and reconstructive surgery·2021

Related Experiment Video

Updated: Mar 27, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

379

Incomplete Reossification After Craniosynostosis Surgery.

Niels Noordzij1, Roma Brouwer, Chantal van der Horst

  • 1*Academic Medical Center, Amsterdam †Medical Center Alkmaar, the Netherlands.

The Journal of Craniofacial Surgery
|January 9, 2016
PubMed
Summary

Incomplete reossification after craniosynostosis surgery, a rare complication, can occur in 0.5-18.2% of cases. Higher age at operation and dura tears increase this risk, necessitating standardized follow-up protocols.

More Related Videos

Author Spotlight: Development and Evaluation of a Standardized Rat Model for Calvarial Suture-Bony Composite Defects
04:17

Author Spotlight: Development and Evaluation of a Standardized Rat Model for Calvarial Suture-Bony Composite Defects

Published on: May 10, 2024

1.7K
Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling
06:51

Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling

Published on: August 18, 2023

2.4K

Related Experiment Videos

Last Updated: Mar 27, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

379
Author Spotlight: Development and Evaluation of a Standardized Rat Model for Calvarial Suture-Bony Composite Defects
04:17

Author Spotlight: Development and Evaluation of a Standardized Rat Model for Calvarial Suture-Bony Composite Defects

Published on: May 10, 2024

1.7K
Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling
06:51

Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling

Published on: August 18, 2023

2.4K

Area of Science:

  • Craniofacial Surgery
  • Pediatric Neurosurgery
  • Plastic Surgery

Background:

  • Craniosynostosis, the premature fusion of cranial sutures, requires surgical intervention to ensure proper brain growth.
  • Open cranial vault remodeling is a common surgical approach for craniosynostosis.
  • Incomplete reossification of the cranial vault after surgery is an uncommon but recognized complication.

Observation:

  • A case of persistent calvarial defect after unicoronal craniosynostosis repair prompted a literature review.
  • The review analyzed incidence, causes, and follow-up of incomplete reossification from 1982-2013.
  • Reported incidence in unselected cohorts varied significantly, ranging from 0.5% to 18.2%.

Findings:

  • Incomplete reossification occurs in both syndromic and non-syndromic craniosynostosis, irrespective of surgical technique.
  • Increased age at the time of surgery and intraoperative dural tears are associated with a higher risk.
  • Follow-up methods (palpation, radiology) and durations (6-264 months) were highly variable.

Implications:

  • Standardized terminology and consistent, long-term follow-up studies are crucial for accurate reporting and understanding of incomplete reossification.
  • Further research is needed to elucidate the precise mechanisms and optimize management strategies.
  • Improved understanding will enhance patient outcomes and guide future surgical practices in pediatric craniofacial reconstruction.