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Updated: Mar 27, 2026

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes
Published on: April 19, 2024
Vaccine strategies against bacterial pathogens in cystic fibrosis patients
V Le Moigne1, J-L Gaillard2, J-L Herrmann2
1Inserm U1173, UFR des sciences de la santé Simone-Veil, université de Versailles-Saint-Quentin, 78180 Saint-Quentin-en-Yvelines, France.
Abstract:
A large number of cystic fibrosis pathogens such as bacteria of the Burkholderia cepacia complex, Pseudomonas aeruginosa, or Mycobacterium abscessus are associated with complex therapeutic problems due to their inherent resistance to antibiotics. No vaccine is currently available against those pathogens. Vaccines are therefore crucial to combat these multidrug-resistant bacteria in specific clinical situations including cystic fibrosis. Various strategies may be considered to develop these vaccines. Similar virulence factors are expressed during the infection with various pathogens; they could thus be used as antigen to assess cross-protection. Many clinical trials are currently being conducted to try and develop a prophylactic treatment for patients presenting with cystic fibrosis.
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