Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

536
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
536
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

1.5K
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
1.5K
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

1.5K
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
1.5K
Drug Dependence01:17

Drug Dependence

1.9K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.9K
Depressants01:28

Depressants

576
Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
576
Diagnostic and Statistical Manual of Mental Disorders (DSM)01:27

Diagnostic and Statistical Manual of Mental Disorders (DSM)

1.7K
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anxiety, Bipolar, Depressive, and Schizophrenia Diagnoses Among Patients Receiving Addiction Treatment in the United States, 2006-2022: A Descriptive Study.

Substance use & addiction journal·2026
Same author

Best Practices for Hospital-Based Initiation of Medications for Opioid Use Disorder: A Consensus Statement.

JAMA network open·2026
Same author

Brain penetrant calcium channel blockers do not reduce alcohol consumption: Converging results from two large independent cohort studies using electronic health records.

medRxiv : the preprint server for health sciences·2026
Same author

Latent classes of sleep deficiency and correlates among patients receiving methadone treatment: A longitudinal study.

Addiction (Abingdon, England)·2026
Same author

An adapted brief negotiation interview for alcohol and cannabis use among assault-injured emerging adults: A randomized pilot trial protocol.

Contemporary clinical trials·2026
Same author

Bridging genomics and pharmacoepidemiology to expand treatment options for alcohol use disorder.

Alcohol, clinical & experimental research·2026

Related Experiment Video

Updated: Mar 27, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

1.7K

In the Clinic. Alcohol Use.

E Jennifer Edelman, David A Fiellin

    Annals of Internal Medicine
    |January 10, 2016
    PubMed
    Summary

    This clinical overview examines alcohol use, covering its health benefits, harms, prevention, screening, diagnosis, and treatment. It emphasizes practice improvement strategies for healthcare professionals.

    Area of Science:

    • Clinical Medicine
    • Public Health
    • Internal Medicine

    Background:

    • Alcohol use is a significant public health concern with wide-ranging health implications.
    • Understanding the multifaceted nature of alcohol use is crucial for effective clinical practice.

    Purpose of the Study:

    • To provide a comprehensive clinical overview of alcohol use.
    • To cover key aspects including health benefits, harms, prevention, screening, diagnosis, and treatment.
    • To guide practice improvement in managing alcohol-related health issues.

    Main Methods:

    • Content is derived from clinical information and education resources of the American College of Physicians (ACP).
    • Includes material from the Medical Knowledge and Self-Assessment Program (MKSAP).

    More Related Videos

    Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
    07:31

    Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

    Published on: January 7, 2019

    8.8K
    Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
    08:45

    Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

    Published on: November 8, 2024

    1.5K

    Related Experiment Videos

    Last Updated: Mar 27, 2026

    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
    05:12

    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

    Published on: June 23, 2023

    1.7K
    Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
    07:31

    Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

    Published on: January 7, 2019

    8.8K
    Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
    08:45

    Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

    Published on: November 8, 2024

    1.5K
  • Developed by Annals of Internal Medicine editors in collaboration with ACP divisions and medical writers.

    • Main Results:

    • The issue offers a detailed clinical perspective on alcohol use.
    • It synthesizes current knowledge on the spectrum of alcohol's effects on health.
    • Provides actionable insights for healthcare providers.

    Conclusions:

    • This resource aims to enhance the clinical management of alcohol use.
    • It supports healthcare professionals in addressing alcohol-related health concerns effectively.
    • Promotes improved patient outcomes through evidence-based practice.