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Related Concept Videos

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance01:25

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

340
In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance...
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Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

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The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
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Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

307
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
307
Renal Clearance01:23

Renal Clearance

3.2K
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
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Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

549
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
549
Renal Drug Clearance: Comparison Between Renal Excretion Methods01:08

Renal Drug Clearance: Comparison Between Renal Excretion Methods

764
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
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Recognition and Sensing of Creatinine.

Tomàs Guinovart1, Daniel Hernández-Alonso2, Louis Adriaenssens2,3

  • 1Department of Analytical and Organic Chemistry, Rovira i Virgili University, C/ Marcel⋅lí Domingo 1, 43007, Tarragona, Spain.

Angewandte Chemie (International Ed. in English)
|January 11, 2016
PubMed
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A novel synthetic receptor offers a simple, accurate, and affordable method for quantifying creatinine. This breakthrough enables rapid detection of creatinine levels in biological fluids like urine and plasma.

Keywords:
cavitandscreatinineionophoresmolecular recognitionsensors

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Area of Science:

  • Chemical Sensors
  • Supramolecular Chemistry
  • Analytical Chemistry

Background:

  • Current creatinine quantification methods lack a balance of accuracy, simplicity, and cost-effectiveness.
  • Accurate monitoring of creatinine is crucial for diagnosing kidney function and related diseases.

Purpose of the Study:

  • To develop a novel synthetic receptor for selective and sensitive creatinine detection.
  • To create a cost-effective and user-friendly potentiometric sensor for biological fluid analysis.

Main Methods:

  • Synthesis of an aryl-substituted calix[4]pyrrole with a monophosphonate bridge as a receptor.
  • Incorporation of the receptor into a polymeric membrane to form a potentiometric sensor.
  • Testing the sensor's performance for creatinine determination in biological samples.

Main Results:

  • The synthetic receptor demonstrated remarkable affinity for creatinine and the creatininium cation.
  • The developed potentiometric sensor exhibited high sensitivity and selectivity for creatinine.
  • The sensor provided accurate, fast, and simple determination of creatinine levels.

Conclusions:

  • The novel synthetic receptor and potentiometric sensor offer a significant advancement in creatinine quantification.
  • This method presents a cost-effective and practical solution for clinical diagnostics and biological fluid analysis.