Telemetry-derived heart rate variability responses to a physical stressor

Analysis of heart rate variability (HRV) responses to an orthostatic challenge can be used to investigate autonomic control of heart rate, an index of cardiovascular function. HRV is typically assessed using the electrocardiogram (ECG), which can be impractical for use with large population-based studies.

To assess the validity and reliability of telemetry-derived HRV responses to an orthostatic challenge.

Twenty healthy adults (26 + 5 years, 45% male) were tested on three separate mornings. Following 20-min supine rest, R-R intervals were recorded using a telemetric device during three conditions: BASE, TILT and RECOVERY. ECG was simultaneously used on 1 day for validity comparison. Measures of HRV included the following: standard deviation of normal-to-normal intervals (SDNN), the root-mean-square of successive differences (RMSSD) and the low-frequency (LF) and high-frequency (HF) spectral power.

For all parameters, there was excellent agreement between devices for BASE (r = 0·96-0·99), TILT (r = 0·89-1·00) and RECOVERY (r = 0·96-1·00). For the telemetric device, between-day intraclass coefficient values for RMSDD, SDNN and HF were all above the 0·75 criterion for each condition, indicating excellent between-day reliability. For each condition, the reliability coefficient, expressed as a percentage of the mean (RC%), was marginally lower (greater reliability) for RMSDD (RC% 11-13) and SDNN (RC% 10-12) compared to HF (RC% 12-17). However, SDNN did not significantly respond to the orthostatic challenge.

Telemetric HRV, particularly RMSDD and HF, can be used to provide a sensitive, valid and reliable assessment of autonomic control of heart rate.