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Recombinant immune complexes as versatile and potent vaccines

Hugh S Mason1

  • 1a Biodesign Institute and School of Life Sciences, Arizona State University , Tempe , AZ , USA.

Human Vaccines & Immunotherapeutics
|January 12, 2016
PubMed

Immune complexes (IC) used as vaccines have the potential to enhance both antibody and cell-mediated immune responses over those obtained with antigen alone. However, difficulty of manufacture represents a significant hurdle to the widespread use of IC as vaccines. Recombinant IC (RIC) and their expression in plants enable manufacturing by the coordinate expression of immunoglobulin and antigen as a fusion protein. The use of a modular RIC system facilitates insertion of antigen genes and provides a broadly applicable platform that can be adapted for a wide variety of antigens.

Keywords:
antibody fusionimmune complexrecombinant planttransient expressionvaccine

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